Apolo

Atividade

120772 - Imunodeficiências Primárias - II

Período da turma:

01/03/2023 a 01/03/2024

Selecione um horário para exibir no calendário:

Descrição:

Avaliação das doenças decorrentes de alterações primárias do sistema imunológico mais comuns

em adultos, tais como: imunodeficiências humorais (ICV, deficiências de IgA, deficiência de

subclasses de IgG, deficiências específicas de anticorpos), deficiências celulares, deficiências de

fagócitos (doenças granulomatosa crônica, síndrome de hiper IgE) e de complemento

(angioedema hereditário). Enfoque em manifestações clínicas, fisiopatologia, diagnóstico

laboratorial, profilaxia e tratamento. Diagnóstico diferencial com imunodeficiências secundárias a

uso de medicamentos, neoplasias, imunossupressores e imunobiológicos. Indicação do uso de

imunomoduladores, imunossupressores e imunobiológicos.

REFERÊNCIAS LIVROS-TEXTO●Solé D, Rosário N, Rubini N. Compêndio de Alergia e Imunologia Clínica: do básico à prática clínica – São Paulo, Editora dos Editores, 2021.● Middleton Jr. E et al. Middleton´Allergy: Principles and Practice, 9th Ed, 2019.● Abbas AK , et al. Celullar and Molecular Immunology - 10th Edition, 2022 ●Kalil J, Motta AA, Agondi R. Alergia e Imunologia- Aplicação Clínica. 2ª edição.2021.● Sullivan KE, Stiehm RE. Stiehm's Immune Deficiencies. Inborn Errors of Immunity. 2nd edition. 2020.

REFERÊNCIAS_PERIÓDICOS (dos últimos 3 anos) ●Allergy Current Opinion in Allergy and Clinical Immunology J Allergy Clinical Immunology J Allergy Clinical Immunology: in Practice Pediatric Allergy and Allergy Current Opinion in Allergy and Clinical Immunology J Allergy Clinical Immunology J Allergy Clinical Immunology: in Practice Pediatric Allergy and Immunology Revista da ASBAI - Arquivos de Asma, Alergia e Imunologia (AAAI) Revista da SBP - Jornal de Pediatria.

REFERÊNCIAS_OUTRAS ● Bousfiha A, Jeddane L, Picard C, Al-Herz W, Ailal F, Chatila T, et al. Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. J Clin Immunol. 2020;40:66-81. ● Tangye et al. Human Inborn Errors of Immunity: 2022 Update on the Classification from the International Union of Immunological Societies Expert Committee. J Clin Immunol 42, 1473–1507 (2022). https://doi.org/10.1007/s10875-022-01289-3 ● Tangye SG, Al-Herz W, Bousfiha A, Cunningham-Rundles C, Franco JL, Holland SM et al. The Ever-Increasing Array of Novel Inborn Errors of Immunity: an Interim Update by the IUIS Committee. J Clin Immunol. 2021 Apr;41(3):666-679.
● Cordero E, Goycochea-Valdivia W, Mendez-Echevarria A, Allende LM, Alsina L, Bravo Garcia-Morato M, et al. Executive summary of the Consensus Document on the diagnosis and management of patients with primary immunodeficiencies. J Allergy Clin Immunol Pract. 2020;8:3342-7. ● Bethune C, Egner W, Garcez T , Huissoon A, Jolles S, Karim Y et al. British Society for Immunology/United Kingdom Primary Immunodeficiency Network consensus statement on managing non-infectious complications of common variable immunodeficiency disorders. Clinical and Experimental Immunology, 2019; 196: 328–35 .. ● Puck JM. Newborn screening for severe combined immunodeficiency and T-cell lymphopenia. Immunol Rev. 2019;287:241-52
● Brodszki N, Frazer-Abel A, Grumach AS, Kirschfink M, Litzman J, Perez E, et al. European Society for Immunodeficiencies (ESID) and European Reference Network on Rare Primary Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN RITA) Complement Guideline: Deficiencies, Diagnosis, and Management. J Clin Immunol. 2020;40:576-91.
● Germenis AE, Margaglione M, Pesquero JB, Farkas H, Cichon S, Csuka D, et al. International Working Group. International Consensus on the Use of Genetics in the Management of Hereditary Angioedema. J Allergy Clin Immunol Pract. 2019.
● Smits et al. Immunoglobulin replacement therapy versus antibiotic prophylaxis as treatment for incomplete primary antibody deficiency. Journal of Clinical Immunology, 2021; 41:382–392, https://doi.org/10.1007/s10875-020-00841-3.
● Tuano et al. Chinen J. Secondary immunodeficiencies: an overview. Ann Allergy Asthma Immunol. 2021, 127: 617−626, https://doi.org/10.1016/j.anai.2021.08.413.
● Patel SY, Carbone J, Jolles S. The Expanding Field of Secondary Antibody Deficiency: Causes, Diagnosis, and Management. Front. Immunol. 2019; https://doi.org/10.3389/fimmu.2019.00033
● Otani et al. Practical guidance for the diagnosis and management of secondary hypogammaglobulinemia: a Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees. J Allergy Clin Immunol. 2022; 149: 1525-60.
● Bucciol et al. Defining Polysaccharide Antibody Deficiency: Measurement of Anti-Pneumococcal Antibodies and Anti-Salmonella typhi Antibodies in a Cohort of Patients with Recurrent Infections. J Clin Immunol. 2020 Jan;40(1):105-113. doi: 10.1007/s10875-019-00691-8.

Carga Horária:

40 horas

Tipo:

Obrigatória

Vagas oferecidas:

Ministrantes:

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