Apolo

Atividade

105361 - 2.Estatísticas Básicas

Período da turma:

19/05/2022 a 30/06/2022

Selecione um horário para exibir no calendário:

Descrição:

Aula 6 - Estatísticas - Noções básicas:
• Classificação de dados
• Distribuição de dados
• Métodos descritivos para dados categóricos
• Métodos descritivos para dados contínuos

Aula 7 - Resultados de segurança, clínicos e intermediário:
• Confiabilidade das medições
• Validade das medições
• Introdução aos resultados de segurança, clínicos e intermediários

Aula 8 - Testes Estatísticos I:
• Estimativa de parâmetros
• Comparação de médias populacionais (teste t de Student, ANOVA)

Aula 9 - Testes Estatísticos II:
• Qui-quadrado e teste exato de Fisher
• Teste de tassociação para dados categóricos

Aula 10 - Cálculo do tamanho da amostra:
• Variáveis de resposta dicotômicas
• Tamanho da amostra para variáveis contínuas
• Tamanho da amostra para de estudos intervenção e equivalência
• Estimativa de parâmetros de tamanho de amostra
• Exemplo prático: como calcular o tamanho da amostra

Aula 11 - Testes Estatísticos III:
• Testes paramétricos e não paramétricos para mais de duas comparações de grupo (Análise de variância (ANOVA) e KruskalWallis)
• Correlação (coeficiente de correlação de Pearson e Spearman)

Aula 12 - Análise de sobrevida:
• Estimativa da curva de sobrevida (Teste de Kaplan Meier)
• Comparação de duas curvas de sobrevida
• Análise ajustada covariada
• Uso de análise de sobrevida em pesquisa clínica

REFERÊNCIA BIBLIOGRÁFICA:

Bewick V, Cheek L, Ball J. Statistics review 7: correlation and regression. Critical Care 2003, 7(6):451-459. Bewick V, Cheek L, Ball J. Statistics review 8: qualitative data – tests of association. Critical Care 2004, 8(1):46-53.
Bewick V, Cheek L, Ball J. Statistics review 9: one-way analysis of variance. Critical Care 2004, 8(2):130-136. Bewick V, Cheek L, Ball J. Statistics review 10: further nonparametric methods. Critical Care 2004, 8(3):196-199. Chan Y, Walmsley RP. Learning and understanding the Kruskal-Wallis one-way analysis-of-variance-by-ranks test for differences among three or more independent groups. Phys Ther 1997, 77:1755-1762.
Curran-Everett D. Explorations in statistics: hypothesis tests and p values. Adv Physiol Educ 2009, 33:81-86. Greenhalgh T. Statistics for the non-statistician. I: different types of data need different statistical tests. BMJ 1997, 315:364-366.
Hazra A, Gogtay N. Biostatistics series module 1: basics of biostatistics. Indian J Dermat 2016, 61(1):10-20.
Hoekstra R, Kiers HA, Johnson A. Are assumptions of well-known statistical techniques check, and why (not)? Frontiers in Psychology 2012, 3:1-9.
Kao LS, Green CE. Analysis of variance: is there a difference in means and what does it mean? J Surg Res 2008, 144(1):158-170. Kim HY. Analysis of variance (ANOVA) comparing means of more than two groups. Restorative Dentistry Endodontics 2014, http://dx.doi.org/10.5395/rde.2014.39.1.74 . Krousel-Wood MA, Chamber RB, Muntner P. Clinicians' guide to statistics for medical practice and research: part I. Ochsner J 2006, 6(2):68-83.
Lang T, Altman D. Basic statistical reporting for articles published in clinical medical journals: the SAMPL Guidelines. In Smart P, Maisonneuve H, Polderman A (eds). Science Editor's Handbook, European Association of Science Editors, 2013.
McHugh ML. Multiple comparison analysis testing in ANOVA. Biochemia Medica 2011, 21(3):203-209.
Mukaka MM. Statistics corner: a guide to appropriate use of correlation coefficient in medical research. Malawi Med J 2012, 24(3):69-71. Prinia S, Gupta N, Verma R. Censoring in clinical trials: review of survival analysis techniques. Indian J Community Med 2010, 35(2):217-221.
Schlattmann P, Dirnagl U. Statistics in experimental cerebrovascular research: comparison of more than two groups with a continuous outcome variable. J Cerebral Blood Flow Metabolism 2010, 30:1558-1563.
Thiese MS, Arnold ZC, Walker SD. The misuse and abuse of statistics in biomedical research. Biochemia Medica 2015, 25(1):5-11. Whitley E, Ball J. Statistics review 3: hypothesis testing and p values. Critical Care 2002, 6(3):222-225.
Whitley E, Ball J. Statistics review 6: nonparametric methods. Critical Care 2002, 6(5):424-428.
Whitley E, Ball J. Statistics review 5: comparison of means. Critical Care 2002, 6(6):509-513.
Winters R, Winters A,Amedee RG. Statistics: a brief overview. Ochsner J 2010, 10:213-216.

Amostragem, validade, viés, randomização e cegamento
Bang H, Ni L, Davis CE. Assessment of blinding in clincal trials. Control Clin Trials 2004, 25:143-156.
Bower P, Brueton V, Gamble C, Treweek S, Smith CT, Young B, Williamson P. Interventions to improve recruitment and retention in clinical trials: a survey and workshop to assess current practice and future priorities. Trials 2014, 15:399.
Bridgman S, Dainty K, Kirkley A, Maffulli N. Practical aspects of randomization and blinding in randomized clinical trials. Arthroscopy 2003, 19(9):1000-1006.
Forder PM, Gebski VJ, Keech AC. Allocation concealment and blinding: when ignorance is bliss. Med J Australia 2005, 182(2):87-89.
Hróbjartsson A, Forfang E, Haahr MT, Als-Nielsen B, Brorson S. Blinded trials taken to the test: an analysis of randomized clinical trials that report tests for the success of blinding. Int J Epidemiol 2007, 36:654-663.
Kang M, Ragan BG, Park JH. Issues in outcomes research: an overview of randomization techniques for clinical trials. J Athletic Train 2008, 43(2):215-221.
Kolahi J, Bang H, Park J. Towards a proposal for assessment of blinding success in clinical trials: up-to-date review. Comm Dent Oral Epidemiol 2009, 37(6):47-484.
Kopec JA, JM Esdaile. Bias in case-control studies. A review. J Epidemiol Commun Health 1990, 44:179-186. Lewis SC, Warlow CP. How to spot bias and other potential problems in randomized controlled trials. J Neurol Neurosurg Psychiatry 2004, 75:181-187.
Pannucci CJ, Wilkins EG. Identifying and avoiding bias in research. Plast Reconstr Surg 2010, 126(2):619-625. Sackett DL. Measuring the success of blinding in RCTs: don't, must, can't or needn't? Int J Epidemiol 2007, 36:664-665.
Vickers AJ. How to randomize. J Soc Integr Oncol 2006, 4(4):194-198.
Viera AJ, Bangdiwala SI. Eliminating bias in randomized controlled trials: importance of allocation concealment and masking. Fam Med 2007, 39(2):132-137.

Carga Horária:

12 horas

Tipo:

Obrigatória

Vagas oferecidas:

Ministrantes:

Raymundo Soares de Azevedo Neto

voltar